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Meta-Analysis
. 2013 Jan 24:11:15.
doi: 10.1186/1477-7819-11-15.

Effects of manual lymphatic drainage on breast cancer-related lymphedema: a systematic review and meta-analysis of randomized controlled trials

Tsai-Wei Huang  1 , Sung-Hui Tseng, Chia-Chin Lin, Chyi-Huey Bai, Ching-Shyang Chen, Chin-Sheng Hung, Chih-Hsiung Wu, Ka-Wai Tam
Affiliations
Meta-Analysis

Effects of manual lymphatic drainage on breast cancer-related lymphedema: a systematic review and meta-analysis of randomized controlled trials

Tsai-Wei Huang et al. World J Surg Oncol. .

Abstract

Background: Lymphedema is a common complication of axillary dissection for breast cancer. We investigated whether manual lymphatic drainage (MLD) could prevent or manage limb edema in women after breast-cancer surgery.

Methods: We performed a systematic review and meta-analysis of published randomized controlled trials (RCTs) to evaluate the effectiveness of MLD in the prevention and treatment of breast-cancer-related lymphedema. The PubMed, EMBASE, CINAHL, Physiotherapy Evidence Database (PEDro), SCOPUS, and Cochrane Central Register of Controlled Trials electronic databases were searched for articles on MLD published before December 2012, with no language restrictions. The primary outcome for prevention was the incidence of postoperative lymphedema. The outcome for management of lymphedema was a reduction in edema volume.

Results: In total, 10 RCTs with 566 patients were identified. Two studies evaluating the preventive outcome of MLD found no significant difference in the incidence of lymphedema between the MLD and standard treatment groups, with a risk ratio of 0.63 and a 95% confidence interval (CI) of 0.14 to 2.82. Seven studies assessed the reduction in arm volume, and found no significant difference between the MLD and standard treatment groups, with a weighted mean difference of 75.12 (95% CI, -9.34 to 159.58).

Conclusions: The current evidence from RCTs does not support the use of MLD in preventing or treating lymphedema. However, clinical and statistical inconsistencies between the various studies confounded our evaluation of the effect of MLD on breast-cancer-related lymphedema.

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Figures

Figure 1
Figure 1
Flowchart of the selection of the clinical trials.
Figure 2
Figure 2
Forest plot of the comparison of the effect of standard treatment with or without manual lymphatic drainage (MLD) on the incidence of post-mastectomy lymphedema from 2 clinical trials. The first author names and the 95% confidence interval (CI) are included.
Figure 3
Figure 3
Forest plot of comparison of the effect of compression therapy with or without manual lymphatic drainage (MLD) on the reduction in post-mastectomy lymphedema volume from 6 clinical trials. The first author names, the standard deviations (SDs) of the mean, and the 95% confidence interval (CI) are included.
See this image and copyright information in PMC

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