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Comment
. 2013 Jan 24;14(1):101.
doi: 10.1186/gb-2013-14-1-101.

Thick and thin fingers point out Turing waves

Andrew D Economou, Jeremy B A Green
Comment

Thick and thin fingers point out Turing waves

Andrew D Economou et al. Genome Biol. .

Abstract

Mouse genetics and computer simulations demonstrate that digit number and width are controlled by a Turing-type mechanism in which distal Hox genes modulate periodicity.

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Figures

Figure 1
Figure 1
Modulation of periodicity along the proximodistal axis of the handplate. (a) Schematic of an embryonic Gli3 null limb showing a polydactylous array of digits fanned across the handplate. Proximal to left, distal to right. (b) Proximal (red) and distal (green) regions of the striped pattern along the anterioposterior axis of the handplate at the positions marked by boxes in (a) illustrate that to maintain the number of digits along the proximodistal axis of the handplate, periodicity must scale with proximodistal position (λ2 > λ1).
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References

    1. Zeller R, Lopez-Rios J, Zuniga A. Vertebrate limb bud development: moving towards integrative analysis of organogenesis. Nat Rev Genet. 2009;10:845–858. doi: 10.1038/nrg2681. - DOI - PubMed
    1. Sheth R, Marcon L, Bastida MF, Junco M, Quintana L, Dahn R, Kmita M, Sharpe J, Ros MA. Hox genes regulate digit patterning by controlling the wavelength of a Turing-type mechanism. Science. 2012;338:1476–1480. doi: 10.1126/science.1226804. - DOI - PMC - PubMed
    1. Turing AM. The chemical basis of morphogenesis. Philos Trans R Soc B. 1952;237:37–72. doi: 10.1098/rstb.1952.0012. - DOI
    1. Meinhardt H, Gierer A. Pattern formation by local self-activation and lateral inhibition. Bioessays. 2000;22:753–760. doi: 10.1002/1521-1878(200008)22:8<753::AID-BIES9>3.0.CO;2-Z. - DOI - PubMed
    1. Miura T, Shiota K, Morriss-Kay G, Maini PK. Mixed-mode pattern in Doublefoot mutant mouse limb - Turing reaction-diffusion model on a growing domain during limb development. J Theor Biol. 2006;240:562–573. doi: 10.1016/j.jtbi.2005.10.016. - DOI - PubMed

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