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. 2013 Feb;27(2):265-70; quiz 271.
doi: 10.1038/eye.2012.276. Epub 2013 Jan 25.

Association of LIPC and advanced age-related macular degeneration

J Lee  1 , J Zeng, G Hughes, Y Chen, S Grob, L Zhao, C Lee, M Krupa, J Quach, J Luo, J Zeng, X Wei, X Zhang, J Zhu, Y Duan, H Ferreyra, M Goldbaum, W Haw, P X Shaw, L Tang, K Zhang
Affiliations

Association of LIPC and advanced age-related macular degeneration

J Lee et al. Eye (Lond). 2013 Feb.

Abstract

Purpose: To determine whether there is an association between hepatic lipase (LIPC) and age-related macular degeneration (AMD) in two independent Caucasian cohorts.

Methods: A discovery cohort of 1626 patients with advanced AMD and 859 normal controls and a replication cohort of 2159 cases and 1150 controls were genotyped for two single-nucleotide polymorphisms (SNPs) in the promoter region of LIPC. The associations between the SNPs and AMD were examined by χ(2) tests.

Results: In the discovery cohort, rs493258 and rs10468017 were both associated with advanced AMD (P=9.63E-3 and P=0.048, respectively). The association was corroborated in the replication cohort (P=4.48E-03 for rs493258 and P=0.015 for rs10468017). Combined analysis resulted in even more significant associations (P=1.21E-04 for rs493258 and P=1.67E-03 for rs10468017).

Conclusion: The LIPC promoter variants rs493258 and rs10468017 were associated with advanced AMD in two independent Caucasian populations, confirming that LIPC polymorphisms may be a genetic risk factor for AMD in the Caucasian population.

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