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. 2013 Feb;27(2):265-70; quiz 271.
doi: 10.1038/eye.2012.276. Epub 2013 Jan 25.

Association of LIPC and advanced age-related macular degeneration

J Lee  1 , J Zeng, G Hughes, Y Chen, S Grob, L Zhao, C Lee, M Krupa, J Quach, J Luo, J Zeng, X Wei, X Zhang, J Zhu, Y Duan, H Ferreyra, M Goldbaum, W Haw, P X Shaw, L Tang, K Zhang
Affiliations

Association of LIPC and advanced age-related macular degeneration

J Lee et al. Eye (Lond). 2013 Feb.

Abstract

Purpose: To determine whether there is an association between hepatic lipase (LIPC) and age-related macular degeneration (AMD) in two independent Caucasian cohorts.

Methods: A discovery cohort of 1626 patients with advanced AMD and 859 normal controls and a replication cohort of 2159 cases and 1150 controls were genotyped for two single-nucleotide polymorphisms (SNPs) in the promoter region of LIPC. The associations between the SNPs and AMD were examined by χ(2) tests.

Results: In the discovery cohort, rs493258 and rs10468017 were both associated with advanced AMD (P=9.63E-3 and P=0.048, respectively). The association was corroborated in the replication cohort (P=4.48E-03 for rs493258 and P=0.015 for rs10468017). Combined analysis resulted in even more significant associations (P=1.21E-04 for rs493258 and P=1.67E-03 for rs10468017).

Conclusion: The LIPC promoter variants rs493258 and rs10468017 were associated with advanced AMD in two independent Caucasian populations, confirming that LIPC polymorphisms may be a genetic risk factor for AMD in the Caucasian population.

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References

    1. Friedman DS, O'Colmain BJ, Munoz B, Tomany SC, McCarty C, de Jong PT, et al. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol. 2004;122 (4:564–572. - PubMed
    1. Cameron DJ, Yang Z, Gibbs D, Chen H, Kaminoh Y, Jorgensen A, et al. HTRA1 variant confers similar risks to geographic atrophy and neovascular age-related macular degeneration. Cell Cycle. 2007;6 (9:1122–1125. - PubMed
    1. Khan JC, Thurlby DA, Shahid H, Clayton DG, Yates JR, Bradley M, et al. Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation. Br J Ophthalmol. 2006;90 (1:75–80. - PMC - PubMed
    1. Seddon JM, Santangelo SL, Book K, Chong S, Cote J. A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions. Am J Hum Genet. 2003;73 (4:780–790. - PMC - PubMed
    1. Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA. 2005;102 (20:7227–7232. - PMC - PubMed

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