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Comment
. 2013 Feb;123(2):558-60.
doi: 10.1172/JCI67887. Epub 2013 Jan 25.

Why stress is BAD for cancer patients

Archana S Nagaraja  1 , Guillermo N Armaiz-Pena, Susan K Lutgendorf, Anil K Sood
Affiliations
Comment

Why stress is BAD for cancer patients

Archana S Nagaraja et al. J Clin Invest. 2013 Feb.

Abstract

Behavioral stress is known to promote tumor progression in experimental models, but the role of behavioral stress in cancer initiation is less clear. In this issue, Hassan et al. focus on the signaling and biological effects induced by stress hormones that lead to tumor cell evasion from apoptosis, resulting in prostate cancer progression.

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Figures

Figure 1
Figure 1. Hassan et al. explored the role of stress in two models of prostate cancer (9).
(A) In an androgen-independent Pten mutant model, signaling through the adrenergic receptor led to phosphorylation (and inactivation) of the proapoptotic molecule BAD, promoting survival of prostate cancer cells. (B) In an androgen-dependent model, stress signaling blocked apoptosis by the PKA/BAD pathway and contributed to androgen therapy resistance.
See this image and copyright information in PMC

Comment on

  • Behavioral stress accelerates prostate cancer development in mice.
    Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R Jr, Danial N, Datta SR, Kulik G. Hassan S, et al. J Clin Invest. 2013 Feb;123(2):874-86. doi: 10.1172/JCI63324. Epub 2013 Jan 25. J Clin Invest. 2013. PMID: 23348742 Free PMC article.

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