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. 2013 Jan 24;18(2):1434-46.
doi: 10.3390/molecules18021434.

Cytotoxicity and anti-inflammatory activity of methylsulfanyl-triazoloquinazolines

Rashad A Al-Salahi  1 , Amira M Gamal-Eldeen, Amer M Alanazi, Mohamed A Al-Omar, Mohamed A Marzouk, Moustafa M G Fouda
Affiliations

Cytotoxicity and anti-inflammatory activity of methylsulfanyl-triazoloquinazolines

Rashad A Al-Salahi et al. Molecules. .

Retraction in

Abstract

A series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 1-25 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence of the inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α (TNF-α), prostaglandin E-2 (PGE-2) and in bacterial lipopolysachharide (LPS)-stimulated macrophages]. The findings revealed that compounds 13 and 17 showed the highest cytotoxicity and that 3, 6-8 and 25 are promising multi-potent anti-inflammatory agents.

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Figures

Scheme 1
Scheme 1
Synthesis of 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazolin-5-one and its derivatives 1–25.
Figure 1
Figure 1
The effect of the synthesized compounds (20 µg/mL) on the growth of macrophages.
Figure 2
Figure 2
The inhibitory effect of the synthesized compounds (20 µg/mL) on the generation of NO (using nitrites index) from LPS-stimulated macrophages.
See this image and copyright information in PMC

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