Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Feb;62(2):339-40.
doi: 10.2337/db12-1171.

LADA: time for a new definition

Maria J Redondo  1
Affiliations
Comment

LADA: time for a new definition

Maria J Redondo. Diabetes. 2013 Feb.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Model of progression to diabetes determined by insulin secretion and insulin resistance. Clinical diabetes manifests when anti-islet autoimmunity (in T1D) or nonautoimmune β-cell dysfunction (in T2D) decrease insulin secretory capacity below a threshold determined by insulin resistance, which can vary from low (in T1D) to high (in T2D). Although not illustrated in this figure, variation in the rate of insulin secretion decrease also determines time to progression to diabetes. In LADA, as opposed to T1D and T2D, three mechanisms, namely, anti-islet autoimmunity, nonautoimmune β-cell dysfunction, and elevated insulin resistance, likely contribute to disease.
See this image and copyright information in PMC

Comment on

References

    1. Zhou Z, Xiang Y, Ji L, et al. on behalf of the LADA China Study Group Frequency, immunogenetics, and clinical characteristics of latent autoimmune diabetes in China (LADA China Study): a nationwide, multicenter, clinic-based cross-sectional study. Diabetes 2013;62:543–550 - PMC - PubMed
    1. Groop LC, Bottazzo GF, Doniach D. Islet cell antibodies identify latent type I diabetes in patients aged 35-75 years at diagnosis. Diabetes 1986;35:237–241 - PubMed
    1. Tuomi T, Groop LC, Zimmet PZ, Rowley MJ, Knowles W, Mackay IR. Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes 1993;42:359–362 - PubMed
    1. Pozzilli P, Di Mario U. Autoimmune diabetes not requiring insulin at diagnosis (latent autoimmune diabetes of the adult): definition, characterization, and potential prevention. Diabetes Care 2001;24:1460–1467 - PubMed
    1. Fourlanos S, Dotta F, Greenbaum CJ, et al. Latent autoimmune diabetes in adults (LADA) should be less latent. Diabetologia 2005;48:2206–2212 - PubMed