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Comment
. 2013 Feb;62(2):343-5.
doi: 10.2337/db12-1193.

Microvascular contributions to insulin resistance

Stephen Rattigan  1 , Stephen M Richards, Michelle A Keske
Affiliations
Comment

Microvascular contributions to insulin resistance

Stephen Rattigan et al. Diabetes. 2013 Feb.
No abstract available

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Figures

FIG. 1.
FIG. 1.
In insulin-sensitive subjects, muscle glucose uptake after a meal is stimulated as outlined in the green pathway. The process involves an insulin-mediated stimulation of muscle microvascular perfusion that increases insulin (INS) and glucose (GLU) delivery to the myocyte, leading to GLUT4 translocation and thus increased muscle glucose uptake. Insulin resistance leading to decreased muscle glucose can occur by pathways outlined in red. If there is an impaired microvascular perfusion due to either capillary rarefaction (left side) or impairment of insulin signaling in the endothelium (right side), the decreased delivery of insulin can limit GLUT4 translocation in the myocyte and, along with decreased glucose delivery, reduce muscle glucose uptake.
See this image and copyright information in PMC

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