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Clinical Trial
. 2013 Oct;22(5):744-7.
doi: 10.1016/j.breast.2012.12.012. Epub 2013 Jan 22.

Toxicity and cosmesis following partial breast irradiation consisting of 40 Gy in 10 daily fractions

Marco Trovo  1 , Mario Roncadin, Jerry Polesel, Erica Piccoli, Mario Mileto, Elvia Micheli, Tiziana Perin, Antonino Carbone, Samuele Massarut, Mauro G Trovo
Affiliations
Clinical Trial

Toxicity and cosmesis following partial breast irradiation consisting of 40 Gy in 10 daily fractions

Marco Trovo et al. Breast. 2013 Oct.

Abstract

Purpose: To assess the toxicity and cosmetic results in breast cancer patients undergoing adjuvant partial breast irradiation (PBI) to a total dose of 40 Gy in 10 daily fractions (4 Gy/fraction).

Methods and materials: Patients affected by early-stage breast cancer were enrolled in this phase II trial. Patients had to be 60 years old and treated with breast conservative surgery for early stage (pT1-T2 pN0-N1a) invasive ductal carcinoma.

Results: 77 patients were enrolled. Median follow-up was 18 months. The proposed schedule was well tolerated. One patient reported Grade 3 pain at the site of irradiation. Four (5%) patients experience Grade 2 erythema. Late Grade 2 and 1 fibrosis was observed in 3 (4%) and 14 (18%) patients, respectively. Cosmesis was judged "good/excellent" and "poor" in 75 (97%) and in 2 (3%) patients, respectively.

Conclusions: 40 Gy in 10 daily fractions, 4 Gy/fraction, is a well tolerated regimen to deliver PBI.

Keywords: Breast cancer; Cosmesis; Hypofractionation; Partial breast irradiation; Toxicity.

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