Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Feb 1;41(1):79-83.
doi: 10.1042/BST20120268.

The role of palmitoylation in regulating Ras localization and function

Sharon Eisenberg  1 , Alex J Laude, Alison J Beckett, Craig J Mageean, Veronica Aran, Maria Hernandez-Valladares, Yoav I Henis, Ian A Prior
Affiliations
Review

The role of palmitoylation in regulating Ras localization and function

Sharon Eisenberg et al. Biochem Soc Trans. .

Abstract

Ras GTPases are important regulators of pathways controlling proliferation, differentiation and transformation. Three ubiquitously expressed almost identical Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization to influence the spatiotemporal signalling of Ras.

PubMed Disclaimer

Publication types