Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jun;64(6):3056-8.
doi: 10.1128/JVI.64.6.3056-3058.1990.

Retroviral integration sites in transgenic Mov mice frequently map in the vicinity of transcribed DNA regions

K Mooslehner  1 , U Karls, K Harbers
Affiliations

Retroviral integration sites in transgenic Mov mice frequently map in the vicinity of transcribed DNA regions

K Mooslehner et al. J Virol. 1990 Jun.

Abstract

Transcription of cellular sequences flanking proviral insertion sites was studied in several Mov mouse strains, each of which carried one copy of the Moloney murine leukemia virus in its germ line. In three out of five randomly chosen Mov strains, the provirus had integrated in the vicinity of DNA regions transcribed in the embryonal stem cell line CCE and the embryonal carcinoma cell line F9. Assuming that CCE and F9 cells are developmentally equivalent to the early embryonic cells that were infected to establish the Mov strains, our results suggest that retroviruses integrate preferentially into actively transcribed DNA regions.

PubMed Disclaimer

References

    1. J Virol. 1986 Nov;60(2):683-92 - PubMed
    1. Cell. 1986 Jul 4;46(1):19-29 - PubMed
    1. Genes Dev. 1987 Jun;1(4):366-75 - PubMed
    1. Cell. 1988 May 20;53(4):531-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3899-903 - PubMed

Publication types

LinkOut - more resources