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. 2013;3(1):52-7.
Epub 2013 Jan 17.

Regulatory T-cells in chronic lymphocytic leukemia: actor or innocent bystander?

Giovanni D'Arena  1 , Vittorio Simeon, Fiorella D'Auria, Teodora Statuto, Paola Di Sanzo, Laura De Martino, Aurelio Marandino, Michele Sangiorgio, Pellegrino Musto, Vincenzo De Feo
Affiliations

Regulatory T-cells in chronic lymphocytic leukemia: actor or innocent bystander?

Giovanni D'Arena et al. Am J Blood Res. 2013.

Abstract

Regulatory T (Treg) cells are now under extensive investigation in chronic lymphocytic leukemia (CLL). This small subset of T-cells has been, in fact, considered to be involved in the pathogenesis and progression of CLL. However, whether Treg dysregulation in CLL plays a key role or it rather represents a simple epiphenomenon is still matter of debate. In the former case, Treg cells could be appealing for targeting therapies. Finally, Treg cells have also been proposed as a prognostic indicator of the disease clinical course.

Keywords: Tregs; chronic lymphocytic leukemia; prognosis.

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