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Case Reports
. 2012 Sep;24(3):253-6.
doi: 10.1007/s11670-012-0253-1.

CPT-11 Chemotherapy Rescued A Patient with Atypical Sclerosing Epithelioid Fibrosarcoma from Emergent Condition

Chun-Hua Pan  1 , Xi-Qun Han, Jian-Sheng Li
Affiliations
Case Reports

CPT-11 Chemotherapy Rescued A Patient with Atypical Sclerosing Epithelioid Fibrosarcoma from Emergent Condition

Chun-Hua Pan et al. Chin J Cancer Res. 2012 Sep.

Abstract

Sclerosing epithelioid fibrosarcoma (SEF) is a rare and poorly defined variant of fibrosarcoma, but generally insensitive to chemotherapy and progresses with poor prognosis. We report the marvelous effect of irinotecan hydrochloride (CPT-11) chemotherapy in rescuing a patient with atypical SEF from emergent condition, who underwent recurrences after several treatment methods. Small dose of CPT-11 was administered to the patient, with which, the size of superficial mass (cervical lymph node) gradually decreased observed by the naked eyes in 5 days. X-ray and CT image proved a marked reduction in the size of the tumor. CPT-11 is valuable for the treatment of this aggressive sarcoma. In condition of emergency caused by sarcoma oppression, administering a tolerable small dose of topoisomerase I-inhibiting drug could be a beneficial choice.

Keywords: CPT-11; Chemotherapy; Sclerosing epithelioid fibrosarcoma.

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Conflict of interest statement

Disclosure of Potential Conflicts of Interest: No potential conflicts of interest were disclosed.

Figures

Figure 1
Figure 1
Pathology of the case. A and B (HE, ×4) show the distinct capsula of the tumor while in some areas, tumor cell infiltrated into the adjacent muscular tissue. C and D (HE, ×40) show the basic structure of the tumor, with relatively pleomorphic cells and hyper-chromatic nuclei. E (immunohisto-chemical staining of Ki-67, ×40) shows the low proliferative index. F (immunohistochemistry, ×40) shows the strongly positive staining of vimentin.
Figure 2
Figure 2
X-ray images of the chest before and after CPT-11 chemotherapy. The photos were taken on d (−5) (A), taken on d (−1) (B), and taken on d (+5) (C) after chemotherapy. The infection in double sides of the lung was alleviated on d (−1) than d (−5) after antibiotic and supportive treatment. The tumor size was reduced significantly on d (+5) after CPT-11 chemotherapy.
Figure 3
Figure 3
CT images before and after the treatment of CPT-11 [A, C, E, on d (−3); B, D, F, on d (+21)]. A, B: Tumor in the cervical lymph nodes; C, D: Tumor in thorax; E, F: Tumor in epigastrium.
See this image and copyright information in PMC

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