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Multicenter Study
. 2013 Jan 29:8:21.
doi: 10.1186/1748-717X-8-21.

Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century

Adam S Garden  1 , Merrill S Kies, William H Morrison, Randal S Weber, Steven J Frank, Bonnie S Glisson, Gary B Gunn, Beth M Beadle, K Kian Ang, David I Rosenthal, Erich M Sturgis
Affiliations
Multicenter Study

Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century

Adam S Garden et al. Radiat Oncol. .

Abstract

Background: We performed this study to assess outcomes of patients with oropharyngeal cancer treated with modern therapy approaches.

Methods: Demographics, treatments and outcomes of patients diagnosed with Stage 3- 4B squamous carcinoma of the oropharynx, between 2000-2007 were tabulated and analyzed.

Results: The cohort consisted of 1046 patients. The 5-year actuarial overall survival, recurrence-free survival and local-regional control rates for the entire cohort were 78%, 77% and 87% respectively. More advanced disease, increasing T-stage and smoking were associated with higher rates of local-regional recurrence and poorer survival.

Conclusions: Patients with locally advanced oropharyngeal cancer have a relatively high survival rate. Patients' demographics and primary tumor volume were very influential on these favorable outcomes. In particular, patients with small primary tumors did very well even when treatment was not intensified with the addition of chemotherapy.

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Figures

Figure 1
Figure 1
Number of patients treated with conventional radiation techniques and intensity-modulated radiation (IMRT).
Figure 2
Figure 2
Local-regional control rates stratified by smoking. a) stratification by status; b) stratification by pack-year history.
Figure 3
Figure 3
Local-regional control rates stratified by T-category.
Figure 4
Figure 4
Local-regional control rates stratified by use of concurrent chemotherapy (CTX) with radiation and T-category. T1-2, no CTX, n = 470; T1-2, CTX, n = 170; T3-4 no CTX, n = 63; T3-4 CTX, n=343.
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