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Review
. 2013 Feb 11;14(3):285-92.
doi: 10.1002/cbic.201200628. Epub 2013 Jan 29.

Flexibility and reactivity in promiscuous enzymes

Pietro Gatti-Lafranconi  1 , Florian Hollfelder
Affiliations
Review

Flexibility and reactivity in promiscuous enzymes

Pietro Gatti-Lafranconi et al. Chembiochem. .

Abstract

Best of both worlds: The interplay of active site reactivity and the dynamic character of proteins allows enzymes to be promiscuous and--sometimes--remarkably efficient at the same time. This review analyses the roles structural flexibility and chemical reactivity play in the catalytic mechanism of selected enzymes.

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