Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Feb;133(2):EL114-7.
doi: 10.1121/1.4776776.

Neuromuscular induced phonation in a human ex vivo perfused larynx preparation

Gerald Berke  1 , Abie H Mendelsohn, Nelson Scott Howard, Zhaoyan Zhang
Affiliations

Neuromuscular induced phonation in a human ex vivo perfused larynx preparation

Gerald Berke et al. J Acoust Soc Am. 2013 Feb.

Abstract

Considering differences in laryngeal anatomy, degree of control, and range of voice qualities between animals and humans, investigations of the neuromuscular process of voice control are better conducted using a living human larynx in which parametric stimulation of individual laryngeal muscles is possible. Due to difficulties in access and monitoring of laryngeal muscle activities, such investigations are impossible in living human subject experiments. This study reports the recent success in developing an ex vivo perfused human larynx model, which allows parametric muscle stimulation and observation of its influence on phonation of a virtually living human larynx in a well-controlled laboratory environment.

PubMed Disclaimer

References

    1. Chhetri, D. K., Neubauer, J., and Berry, D. A. (2010). “Graded activation of the intrinsic laryngeal muscles for vocal fold posturing,” J. Acoust. Soc. Am. 127, EL127–EL133. - PMC - PubMed
    1. Chhetri, D. K., Neubauer, J., and Berry, D. A. (2012). “Neuromuscular control of fundamental frequency and glottal posture at phonation onset,” J. Acoust. Soc. Am. 131, 1401–1412.10.1121/1.3672686 - DOI - PMC - PubMed
    1. Choi, H.-S., Berke, G. S., Ye, M., and Kreiman, J. (1993a). “Function of the posterior cricoarytenoid muscle in phonation: In vivo laryngeal model,” Otolaryngol.-Head Neck Surg. 109, 1043–1051. - PubMed
    1. Choi, H. S., Berke, G. S., Ye, M., and Kreiman, J. (1993b). “Function of the thyroarytenoid muscle in a canine laryngeal model,” Ann. Otol. Rhinol. Laryngol. 102, 769–776. - PubMed
    1. Hirano, M., and Kakita, Y. (1985). “Cover-body theory of vocal fold vibration,” in Speech Science: Recent Advances, edited by Daniloff R. G. (College-Hill Press, San Diego, CA: ), pp. 1–46.

Publication types

LinkOut - more resources