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. 2013 May 1;63(1):142-5.
doi: 10.1097/QAI.0b013e318288b39d.

Immune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africa

Michael Schomaker  1 , Matthias Egger, Mhairi Maskew, Daniela Garone, Hans Prozesky, Christopher J Hoffmann, Andrew Boulle, Lukas Fenner; IeDEA Southern Africa
Collaborators, Affiliations

Immune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africa

Michael Schomaker et al. J Acquir Immune Defic Syndr. .

Abstract

We studied the immune response after starting antiretroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/µL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.

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Conflict of interest statement

Conflict of interest

All authors none to declare

Figures

Figure 1
Figure 1
Modeled CD4 trajectories defined as CD4 cell count increase from baseline by tuberculosis (TB) status at ART start, according to CD4 cell count at the start of ART of CD4 cell count <50 (A), and CD4 cell count between 50–199 (B).
See this image and copyright information in PMC

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