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. 2012:2012:743-6.
doi: 10.1109/EMBC.2012.6346038.

Polymeric packaging for fully implantable wireless neural microsensors

Juan Aceros  1 , Ming Yin, David A Borton, William R Patterson, Christopher Bull, Arto V Nurmikko
Affiliations

Polymeric packaging for fully implantable wireless neural microsensors

Juan Aceros et al. Annu Int Conf IEEE Eng Med Biol Soc. 2012.

Abstract

We present polymeric packaging methods used for subcutaneous, fully implantable, broadband, and wireless neurosensors. A new tool for accelerated testing and characterization of biocompatible polymeric packaging materials and processes is described along with specialized test units to simulate our fully implantable neurosensor components, materials and fabrication processes. A brief description of the implantable systems is presented along with their current encapsulation methods based on polydimethylsiloxane (PDMS). Results from in-vivo testing of multiple implanted neurosensors in swine and non-human primates are presented. Finally, a novel augmenting polymer thin film material to complement the currently employed PDMS is introduced. This thin layer coating material is based on the Plasma Enhanced Chemical Vapor Deposition (PECVD) process of Hexamethyldisiloxane (HMDSO) and Oxygen (O(2)).

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Figures

Figure 1
Figure 1
(a) 100-Channel Single Front-End Neurosensor, (b) 32-Channel Dual Front-End Neurosensor (access to two cortical sites).
Figure 2
Figure 2
Artificial Spike Signals Sensed Using a 100-Channel Neurosensor.
Figure 3
Figure 3
Test System for Accelerated Testing of Polymeric Materials.
Figure 4
Figure 4
(a) Encapsulation Test Unit. (b) Details of Test Section.
Figure 5
Figure 5
Leakage Current Characterization across the PDMS. Early Failure Appears for ETU 03 and at ~40 days for the others.
Figure 6
Figure 6
IR Absorbance for Various Flow Ratios (HMDSO = 1.0 sccm).
See this image and copyright information in PMC

References

    1. Nurmikko Arto V., Donoghue John P., Hochberg Leigh, Patterson William R., Song Yoon-Kyu, Bull Christopher, Borton David, Laiwalla Farah, Park Sunmee, Ming Yin, Aceros Juan. Listening to Brain Microcircuits for Interfacing with External World – Progress in Wireless Implantable Microelectronic Neuroengineering Devices. Proc. IEEE (invited) 2010;98:375. - PMC - PubMed
    1. Hochberg LR, et al. Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature. 2006;442:164–171. - PubMed
    1. Mandlik Prashant, Gartside Jonathan, Han Lin, Cheng I-Chun, Wagner Sigurd, Silvernail Jeff A., Ma Rui-Qing, Hack Michael, Brown Julie J. A single-layer permeation barrier for organic light-emitting displays. Appl. Phys. Lett. 2008;92:103309.
    1. Aceros Juan, Yin Ming, Borton David, Patterson William, Nurmikko Arto. A 32-channel fully implantable wireless neurosensor for simultaneous recording from two cortical regions. Proc. IEEE 33th Eng. in Med. and Biol. Conf..Aug, 2011. pp. 2300–2306. - PMC - PubMed
    1. Yin M, Borton DA, Aceros J, Patterson WR, Nurmikko AV. A hermetically packaged 100-channel fully implantable wireless neural recording system. Proc. IEEE Intl. Symp. on Circuits and Systems. 2012 May; Accepted.

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