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Review
. 2013 Mar;45(1):60-8.
doi: 10.1111/jnu.12002. Epub 2013 Jan 31.

Cardiovascular genomics

Shu-Fen Wung  1 , Kathleen T Hickey, Jacquelyn Y Taylor, Matthew J Gallek
Affiliations
Review

Cardiovascular genomics

Shu-Fen Wung et al. J Nurs Scholarsh. 2013 Mar.

Abstract

Purpose: This article provides an update on cardiovascular genomics using three clinically relevant exemplars, including myocardial infarction (MI) and coronary artery disease (CAD), stroke, and sudden cardiac death (SCD). ORGANIZATIONAL CONSTRUCT: Recent advances in cardiovascular genomic research, testing, and clinical implications are presented.

Methods: Genomic nurse experts reviewed and summarized recent salient literature to provide updates on three selected cardiovascular genomic conditions.

Findings: Research is ongoing to discover comprehensive genetic markers contributing to many common forms of cardiovascular disease (CVD), including MI and stroke. However, genomic technologies are increasingly being used clinically, particularly in patients with long QT syndrome (LQTS) or hypertrophic cardiomyopathy (HCM) who are at risk for SCD.

Conclusions: Currently, there are no clinically recommended genetic tests for many common forms of CVD even though direct-to-consumer genetic tests are being marketed to healthcare providers and the general public. On the other hand, genetic testing for patients with certain single gene conditions, including channelopathies (e.g., LQTS) and cardiomyopathies (e.g., HCM), is recommended clinically.

Clinical relevance: Nurses play a pivotal role in cardiogenetics and are actively engaged in direct clinical care of patients and families with a wide variety of heritable conditions. It is important for nurses to understand current development of cardiovascular genomics and be prepared to translate the new genomic knowledge into practice.

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References

    1. Ackerman MJ, Priori SG, Willems S, Berul C, Brugada R, Calkins H, Zipes DP. HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Heart Rhythm. 2011;8(8):1308–1339. doi:10.1016/j.hrthm.2011.05.020. - PubMed
    1. Andresdottir MB, Sigurdsson G, Sigvaldason H, Gudnason V, Reykjavik Cohort Study Fifteen percent of myocardial infarctions and coronary revascularizations explained by family history unrelated to conventional risk factors. The Reykjavik Cohort Study. European Heart Journal. 2002;23(21):1655–1663. - PubMed
    1. Benton JL, Ding J, Tsai MY, Shea S, Rotter JI, Burke GL, Post W. Associations between two common polymorphisms in the ABCA1 gene and subclinical atherosclerosis: Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2007;193(2):352–360. doi:10.1016/j.atherosclerosis.2006.06.024. - PubMed
    1. Brass LM, Isaacsohn JL, Merikangas KR, Robinette CD. A study of twins and stroke. Stroke. 1992;23(2):221–223. - PubMed
    1. Broeckel U, Hengstenberg C, Mayer B, Holmer S, Martin LJ, Comuzzie AG, Schunkert H. A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nature Genetics. 2002;30(2):210–214. doi:10.1038/ng827. - PubMed

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