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. 2013 Feb 1:10:42.
doi: 10.1186/1743-422X-10-42.

Sero-epidemiological survey of human cytomegalovirus-infected children in Weifang (Eastern China) between 2009 and 2012

Xiuning Sun  1 , Zhijun Liu, Bin Wang, Lihong Shi, Ruiwen Liang, Ling Li, Dongmeng Qian, Xuxia Song
Affiliations

Sero-epidemiological survey of human cytomegalovirus-infected children in Weifang (Eastern China) between 2009 and 2012

Xiuning Sun et al. Virol J. .

Abstract

Background: To understand the prevalence and characteristics of human cytomegalovirus (HCMV) infection in children in the Weifang area, and to provide information for its prevention and treatment.

Methods: A comprehensive survey was performed from 2009 to 2012 in 7582 children from birth to 6 years of age hospitalized in the Maternity and Child Health Hospital of Weifang. ELISA HCMV serology results and survey data were analyzed by age group and socio-economic level. The infection rates were based on IgG and IgM serology.

Results and conclusions: The overall infection rate from IgG and IgM in the Weifang area from 2009 to 2012 was 42.5% (3496/7582), among which 34.2% were HCMV-IgG positive, suggesting past infection. Overall, the probability of active HCMV infection showed no gender difference in any age group (P >0.05). Recent infections centered on the first 6 months of life, presumably due to breastfeeding. Among the 654 children hospitalized for active HCMV infection, 379 (57.9%) were from rural areas and 275 (42.1%) from urban areas, showing that active infection in the countryside was higher than that in the city (χ2 = 32.65, p <0.01).

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Figures

Figure 1
Figure 1
Total and recent infection rates in different age groups.
See this image and copyright information in PMC

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