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. 2013 Jan;58(1):85.
doi: 10.4103/0019-5154.105323.

Allergic urticaria: a case report of rare skin allergy with a common mouthwash

Viresh Chopra  1 , Harneet Chopra, Anamika Sharma
Affiliations

Allergic urticaria: a case report of rare skin allergy with a common mouthwash

Viresh Chopra et al. Indian J Dermatol. 2013 Jan.

Erratum in

  • Indian J Dermatol. 2013 Sep;58(5):395

Retraction in

  • Retraction notice.
    [No authors listed] [No authors listed] Indian J Dermatol. 2013 Jul;58(4):298. Indian J Dermatol. 2013. PMID: 23919002 Free PMC article. No abstract available.

Abstract

Chlorhexidine is a widely used antiseptic and disinfectant in medical and non-medical environments. Compared to its ubiquitous use, allergic contact dermatitis from chlorhexidine has rarely been reported and so its sensitization rate seems to be low. Chlorhexidine has been used for more than 50 years but it was only in the last two decades, that reports of immediate- type reactions to chlorhexidine were seen. Reactions ranging from localized urticaria to anaphylactic shock and hypersensitivity reactions, including delayed hypersensitivity reactions such as contact dermatitis, fixed drug eruptions, and photosensitivity reactions, began to appear more frequently. However the prevalence of contact urticaria and anaphylaxis due to chlorhexidine remains to be unknown. In this case report we have reported a case of urticaria due to oral use of chlorhexidine. The adverse reaction was confirmed by a skin prick test.

Keywords: Allergic contact dermatitis; Chlorhexidine; chlorhexidine Urticaria; delayed hypersensitivity; urticaria.

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Conflict of interest statement

Conflict of Interest: Nil.

Figures

Figure 1
Figure 1
Redness on forehead and face after first time use of chlorhexidine formulation
Figure 2
Figure 2
Redness on the side of the neck after the use of chlorhexidine formulation
Figure 3
Figure 3
Marked redness on the upper back neck region as a result of chlorhexidine allergy
Figure 4
Figure 4
Redness on forearm and and elbow as a result of chlorhexidine allergy
See this image and copyright information in PMC

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    Koch A, Wollina U. Koch A, et al. Allergo J Int. 2014;23(3):84-86. doi: 10.1007/s40629-014-0012-6. Epub 2014 May 9. Allergo J Int. 2014. PMID: 26120519 Free PMC article. No abstract available.

References

    1. Loe H, Schiott R. The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man. J Periodontol Res. 1970;5:79–83. - PubMed
    1. Addy M, Wright R. Comparison of the in vivo and in vitro antibacterial properties of povidone iodine and chlorhexidine gluconate mouthrinses. J Clin Periodontol. 1978;5:198–205. - PubMed
    1. Schiott CR, Loe H, Jensen SB, Killian M, Davies RM, Glavind K. The effect of chlorhexidine mouthrinses on the human oral flora. J Periodont Res. 1970;5:84–9. - PubMed
    1. Flotra L, Gijermo P, Rolla G, Waerhaug J. Side effects of chlorhexidine mouthwashes. Scand J Dent Res. 1971;79:119–25. - PubMed
    1. Beaudouin E, Kanny G, Morisset M, Renaudin JM, Mertes M, Laxenaire MC, et al. Immediate hypersensitivity to chlorhexidine: Literature review. Allerg Immunol (Paris) 2004;36:123–6. - PubMed

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