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. 2012 Feb;62(1):35-8.
doi: 10.1007/s13224-012-0148-6. Epub 2012 Apr 20.

A randomized controlled trial comparing two different antibiotic regimens for prophylaxis at cesarean section

Gourisankar Kamilya  1 , Subrata Lall Seal, Joydev Mukherji, Himangsu Roy, Subir Kumar Bhattacharyya, Avijit Hazra
Affiliations

A randomized controlled trial comparing two different antibiotic regimens for prophylaxis at cesarean section

Gourisankar Kamilya et al. J Obstet Gynaecol India. 2012 Feb.

Abstract

Objectives: To compare the efficacy of intravenous single dose, less costly cefotaxime and more expensive amoxycillin-clavulanic acid combination for prophylaxis at cesarean section.

Method: A double blind randomized controlled trial was undertaken on 760 subjects with two parallel treatment groups. Data were analyzed using Graphpad Instat 3 McIntosh software by Student's t test, Mann-Whitney U test, the Chi-squared test or fisher's exact test.

Results: Comparatively narrow spectrum low cost cefotaxime is as effective as more expensive commonly used amoxicillin-clavulanic acid with no significant difference of infectious morbidity and hospital stay (p = 0.27 and 0.11 in elective and emergency cases respectively).

Conclusion: Less costly cefotaxime should be preferred compared to more costly amoxicillin-clavulanic acid combination for prophylaxis at cesarean section.

Keywords: Antibiotic; Cesarean section; Prophylaxis.

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Figures

Fig. 1
Fig. 1
Recruitment of cases in two groups
See this image and copyright information in PMC

References

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