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. 2012 Feb;8(1):7-9.
doi: 10.1007/s11420-011-9250-z. Epub 2012 Jan 24.

Articular cartilage degradation in osteoarthritis

Mary B Goldring  1
Affiliations

Articular cartilage degradation in osteoarthritis

Mary B Goldring. HSS J. 2012 Feb.
No abstract available

Keywords: Anesthesiology; Imaging / Radiology; Medicine & Public Health; Orthopedics; Rheumatology; Sports Medicine; Surgical Orthopedics; cartilage; inflammation; osteoarthritis.

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Figures

Fig. 1
Fig. 1
From homeostasis to osteoarthritis. The composition and cellular organization of healthy human adult articular cartilage (left panel) is more complex than it looks in this histological section showing few chondrocytes distributed in matrix with homogeneous appearance and the clear demarcation (tidemark) between the articular cartilage and a thin zone of calcified cartilage next to the underlying subchondral bone. During the development of osteoarthritis, the normally quiescent chondrocytes become activated and undergo a phenotypic shift, resulting in surface fibrillation and degradation of cartilage matrix, the appearance of chondrocyte clusters, increased cartilage calcification associated with tidemark advancement or duplication, and vascular penetration from the subchondral bone (right panel). Histology (Safranin O/Fast green staining) provided by Cecilia Dragomir, Hospital for Special Surgery, New York, NY; ×10 magnification
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