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Review
. 2013 Feb;6(1):1-5.
doi: 10.1093/ckj/sft002. Epub 2012 Jan 1.

Viruses and collapsing glomerulopathy: a brief critical review

Preeti Chandra  1 , Jeffrey B Kopp
Affiliations
Review

Viruses and collapsing glomerulopathy: a brief critical review

Preeti Chandra et al. Clin Kidney J. 2013 Feb.

Abstract

Background: Collapsing glomerulopathy may occur in an idiopathic (primary) form and in association with a wide spectrum of infectious and inflammatory conditions and medications. The association of collapsing glomerulopathy with human immunodeficiency virus (HIV)-1 infection is well established; less certain is the association with other viral infections.

Methods: We searched PubMed for articles in all languages that addressed glomerulopathies associated with parvovirus B19, cytomegalovirus (CMV), Epstein-Barr virus (EBV), hepatitis C virus (HCV) and simian virus 40 (SV40).

Results: Case reports and small-case series link infection with these common viruses and glomerular injury. The evidence for a pathogenic role is generally stronger for glomerulonephritis than for collapsing glomerulopathy.

Conclusions: The evidence linking collapsing glomerulopathy with CMV is relatively strong but not yet conclusive, while the evidence for a pathogenic role for EBV and parvovirus B19 is weaker.

Keywords: Epstein-Barr virus; collapsing focal segmental glomerulosclerosis; cytomegalovirus; parvovirus B19; podocyte.

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