5-Propyl-2'-deoxyuridine: a specific anti-herpes agent
- PMID: 233730
- PMCID: PMC352280
- DOI: 10.1128/AAC.13.3.545
5-Propyl-2'-deoxyuridine: a specific anti-herpes agent
Abstract
In both primary rabbit kidney cells and human skin fibroblasts, 5-propyl-2'-deoxyuridine proved inhibitory to herpes simplex virus at a concentration as low as 1 micrograms/ml, whereas concentrations higher than 200 micrograms/ml were required to inhibit vaccinia virus replication or normal cell metabolism.
Similar articles
-
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.J Med Chem. 1987 Aug;30(8):1494-7. doi: 10.1021/jm00391a036. J Med Chem. 1987. PMID: 3039140
-
Selective in vitro and in vivo activities of 5-(2-haloalkyl)pyrimidine nucleoside analogs, particularly 5-(2-chloroethyl)-2'-deoxyuridine, against herpes simplex virus.Antimicrob Agents Chemother. 1985 Aug;28(2):246-51. doi: 10.1128/AAC.28.2.246. Antimicrob Agents Chemother. 1985. PMID: 3010841 Free PMC article.
-
5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine.J Med Chem. 1978 Feb;21(2):228-31. doi: 10.1021/jm00200a018. J Med Chem. 1978. PMID: 202709
-
5-Substituted 2'-deoxyuridines which selectively inhibit herpes simplex virus replication.Adv Ophthalmol. 1979;38:204-13. Adv Ophthalmol. 1979. PMID: 230717 No abstract available.
-
Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus.J Infect Dis. 1980 May;141(5):563-74. doi: 10.1093/infdis/141.5.563. J Infect Dis. 1980. PMID: 6246180
Cited by
-
Specific targets for antiviral drugs.Biochem J. 1982 Jul 1;205(1):1-13. doi: 10.1042/bj2050001. Biochem J. 1982. PMID: 6181775 Free PMC article. Review. No abstract available.
-
(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.Proc Natl Acad Sci U S A. 1979 Jun;76(6):2947-51. doi: 10.1073/pnas.76.6.2947. Proc Natl Acad Sci U S A. 1979. PMID: 223163 Free PMC article.
-
Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice.Antimicrob Agents Chemother. 1979 Nov;16(5):680-2. doi: 10.1128/AAC.16.5.680. Antimicrob Agents Chemother. 1979. PMID: 526011 Free PMC article.
-
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. doi: 10.1128/AAC.01284-06. Epub 2007 Apr 16. Antimicrob Agents Chemother. 2007. PMID: 17438061 Free PMC article.
-
Possible molecular basis for antiviral activity of certain 5-substituted deoxyuridines.Antimicrob Agents Chemother. 1983 Mar;23(3):416-21. doi: 10.1128/AAC.23.3.416. Antimicrob Agents Chemother. 1983. PMID: 6303212 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources