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Comment
. 2013 Jan 31;152(3):385-6.
doi: 10.1016/j.cell.2013.01.025.

Conformational ensembles in GPCR activation

Eyal Vardy  1 , Bryan L Roth
Affiliations
Free article
Comment

Conformational ensembles in GPCR activation

Eyal Vardy et al. Cell. .
Free article

Abstract

Recent advances in G-protein-coupled receptor structural biology have provided only limited insight into the active conformations of these key signaling molecules. A paper from Nygaard et al. reveals the dynamic nature of GPCRs along the activation pathway by complementing NMR experiments with ultralong-timescale molecular dynamics simulations.

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  • The dynamic process of β(2)-adrenergic receptor activation.
    Nygaard R, Zou Y, Dror RO, Mildorf TJ, Arlow DH, Manglik A, Pan AC, Liu CW, Fung JJ, Bokoch MP, Thian FS, Kobilka TS, Shaw DE, Mueller L, Prosser RS, Kobilka BK. Nygaard R, et al. Cell. 2013 Jan 31;152(3):532-42. doi: 10.1016/j.cell.2013.01.008. Cell. 2013. PMID: 23374348 Free PMC article.

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