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Review
. 2013 Jan 31;152(3):390-3.
doi: 10.1016/j.cell.2013.01.010.

The role of telomeres in stem cells and cancer

Cagatay Günes  1 , K Lenhard Rudolph
Affiliations
Free article
Review

The role of telomeres in stem cells and cancer

Cagatay Günes et al. Cell. .
Free article

Abstract

Telomere shortening impairs proliferation of transformed cells but also leads to cancer initiation by inducing chromosomal instability. Here, we discuss recent developments in our understanding of the role of telomeres in replication stress and how telomerase expression in somatic stem cells may affect genome integrity control and carcinogenesis.

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