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Review
. 2013 Jan-Mar;16(1):33-9.
doi: 10.1016/j.jocd.2012.12.001.

Normocalcemic primary hyperparathyroidism

Natalie E Cusano  1 , Shonni J Silverberg, John P Bilezikian
Affiliations
Review

Normocalcemic primary hyperparathyroidism

Natalie E Cusano et al. J Clin Densitom. 2013 Jan-Mar.

Abstract

Primary hyperparathyroidism, a common endocrine disorder, is traditionally defined by hypercalcemia and elevated levels of parathyroid hormone (PTH). A newer presentation of primary hyperparathyroidism has been described over the past decade, in which PTH is elevated but serum calcium is consistently normal, in the absence of secondary causes of hyperparathyroidism, such as renal disease or vitamin D deficiency. Recognition of this phenotype of primary hyperparathyroidism, normocalcemic primary hyperparathyroidism, supports a biphasic chronological time course in some individuals in which PTH levels are first elevated but serum calcium is normal, followed by the development of frank hypercalcemia. This review focuses on the available literature regarding this newly described phenotype of primary hyperparathyroidism.

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Figures

Figure 1
Figure 1
The two-phase hypothesis of the evolution of primary hyperparathyroidism, from asymptomatic normocalcemic to symptomatic hypercalcemic disease.
See this image and copyright information in PMC

References

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