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. 1990 Apr;28(2):89-91.
doi: 10.1016/0266-4356(90)90128-8.

Local benefit of prostaglandin E2 in radiochemotherapy-induced oral mucositis

M Matejka  1 , A Nell, G Kment, A Schein, M Leukauf, H Porteder, G Mailath, H Sinzinger
Affiliations

Local benefit of prostaglandin E2 in radiochemotherapy-induced oral mucositis

M Matejka et al. Br J Oral Maxillofac Surg. 1990 Apr.

Abstract

In 15 patients suffering from maxillofacial cancer with radiochemotherapy-induced oral mucositis the local application of prostaglandin E2 (PGE2) tablets, 0.5 mg four times a day at a 4-h interval was performed. Plasma determination of the bicyclo-prostaglandin E2 metabolite showed no significant amount of the locally applied substance in the circulation. It is claimed that for this particular indication, PGE2 is a potent locally acting compound without affecting circulating levels.

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