Comparative Study
[System of ethanol and acetaldehyde metabolism in the rat liver during the development of ethanol tolerance]
[Article in
Russian]
- PMID: 2337652
Item in Clipboard
Comparative Study
[System of ethanol and acetaldehyde metabolism in the rat liver during the development of ethanol tolerance]
[Article in
Russian]
Biull Eksp Biol Med.
1990 Feb.
Abstract
Following daily intraperitoneal injections of ethanol at a dose of 3.5 g/kg rats developed tolerance to its hypnotic action, which was manifested in a drastic decrease of ethanol--induced sleep time and the number of animals sleeping more than 60 min. In the liver, this process was characterized by an elevated alcohol dehydrogenase activity and a decreased aldehyde dehydrogenase one, whereas that of MEOS remained unchanged.
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