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Comparative Study
. 1990 Feb;109(2):161-2.

[System of ethanol and acetaldehyde metabolism in the rat liver during the development of ethanol tolerance]

[Article in Russian]
V I Satanovskaia
  • PMID: 2337652
Comparative Study

[System of ethanol and acetaldehyde metabolism in the rat liver during the development of ethanol tolerance]

[Article in Russian]
V I Satanovskaia. Biull Eksp Biol Med. 1990 Feb.

Abstract

Following daily intraperitoneal injections of ethanol at a dose of 3.5 g/kg rats developed tolerance to its hypnotic action, which was manifested in a drastic decrease of ethanol--induced sleep time and the number of animals sleeping more than 60 min. In the liver, this process was characterized by an elevated alcohol dehydrogenase activity and a decreased aldehyde dehydrogenase one, whereas that of MEOS remained unchanged.

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