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Case Reports
. 1990 Apr;60(4):215-8.
doi: 10.1007/BF01728786.

Experimental treatment of chronic lymphocytic leukemia with extracorporeal photochemotherapy. Initial observations

R M Knobler  1 , R Pirker, E M Kokoschka, H Ludwig, W Linkesch, M Micksche
Affiliations
Case Reports

Experimental treatment of chronic lymphocytic leukemia with extracorporeal photochemotherapy. Initial observations

R M Knobler et al. Blut. 1990 Apr.

Abstract

Based on the encouraging results obtained with extracorporeal photochemotherapy (EP) in the treatment of the exfoliative erythrodermic form of cutaneous T-cell lymphoma (CTCL), leukemic form, as well as other T-cell-mediated diseases we evaluated the therapeutic potential of EP in patients with chronic lymphocytic leukemia (B-CLL). Three patients with B-CLL were treated for a period of 1 year. Two patients showed stabilization of disease, as demonstrated by reduction in their peripheral white blood cell count, with one patient showing lymph-node resolution. A third patient with significant intolerance to previous chemotherapy did not respond within the observed period. No significant side effects of EP were observed. Our observations suggest that EP may have a positive effect on the course of B-CLL in selected patients. Additional clinical trials are warranted to further define the role of EP alone or in combination therapy in the management of B-CLL.

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References

    1. J Natl Cancer Inst. 1978 Aug;61(2):337-40 - PubMed
    1. Am J Hematol. 1986 May;22(1):55-61 - PubMed
    1. N Engl J Med. 1974 Dec 5;291(23):1207-11 - PubMed
    1. J Immunol. 1979 Mar;122(3):1087-90 - PubMed
    1. Cell. 1987 Feb 27;48(4):549-54 - PubMed

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