Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Apr;22(4):688-96.
doi: 10.1158/1055-9965.EPI-13-0007-T. Epub 2013 Feb 1.

Genetic variation in the vitamin d pathway in relation to risk of prostate cancer--results from the breast and prostate cancer cohort consortium

Alison M Mondul  1 , Irene M Shui, Kai Yu, Ruth C Travis, Victoria L Stevens, Daniele Campa, Frederick R Schumacher, Regina G Ziegler, H Bas Bueno-de-Mesquita, Sonja Berndt, E D Crawford, Susan M Gapstur, J Michael Gaziano, Edward Giovannucci, Christopher A Haiman, Brian E Henderson, David J Hunter, Mattias Johansson, Timothy J Key, Loïc Le Marchand, Sara Lindström, Marjorie L McCullough, Carmen Navarro, Kim Overvad, Domenico Palli, Mark Purdue, Meir J Stampfer, Stephanie J Weinstein, Walter C Willett, Meredith Yeager, Stephen J Chanock, Dimitrios Trichopoulos, Laurence N Kolonel, Peter Kraft, Demetrius Albanes
Affiliations

Genetic variation in the vitamin d pathway in relation to risk of prostate cancer--results from the breast and prostate cancer cohort consortium

Alison M Mondul et al. Cancer Epidemiol Biomarkers Prev. 2013 Apr.

Abstract

Background: Studies suggest that vitamin D status may be associated with prostate cancer risk although the direction and strength of this association differs between experimental and observational studies. Genome-wide association studies have identified genetic variants associated with 25-hydroxyvitamin D [25(OH)D] status. We examined prostate cancer risk in relation to single-nucleotide polymorphisms (SNP) in four genes shown to predict circulating levels of 25(OH)D.

Methods: SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25(OH)D were genotyped in 10,018 cases and 11,052 controls from the National Cancer Institute (NCI) Breast and Prostate Cancer Cohort Consortium. Logistic regression was used to estimate the individual and cumulative association between genetic variants and risk of overall and aggressive prostate cancer.

Results: We observed a decreased risk of aggressive prostate cancer among men with the allele in rs6013897 near CYP24A1 associated with lower serum 25(OH)D [per A allele, OR, 0.86; 95% confidence interval (CI), 0.80-0.93; Ptrend = 0.0002) but an increased risk for nonaggressive disease (per A allele: OR, 1.10; 95% CI, 1.04-1.17; Ptrend = 0.002). Examination of a polygenic score of the four SNPs revealed statistically significantly lower risk of aggressive prostate cancer among men with a greater number of low vitamin D alleles (OR for 6-8 vs. 0-1 alleles, 0.66; 95% CI, 0.44-0.98; Ptrend = 0.003).

Conclusions: In this large, pooled analysis, genetic variants related to lower 25(OH)D levels were associated with a decreased risk of aggressive prostate cancer.

Impact: Our genetic findings do not support a protective association between loci known to influence vitamin D levels and prostate cancer risk.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors have nothing to disclose

Figures

Figure 1
Figure 1
Association* Between 4-SNP Score and Risk of Overall Prostate Cancer * - Adjusted for age (5-year groups) and study
Figure 2
Figure 2
Association* Between 4-SNP Score and Risk of Aggressive and Non-Aggressive Prostate Cancer *-Adjusted for age (5-year groups) and study
See this image and copyright information in PMC

References

    1. Bouillon R, Eelen G, Verlinden L, Mathieu C, Carmeliet G, Verstuyf A. Vitamin D and cancer. J Steroid Biochem Mol Biol. 2006;102:156–62. - PubMed
    1. Holick MF. Vitamin D: its role in cancer prevention and treatment. Prog Biophys Mol Biol. 2006;92:49–59. - PubMed
    1. Fleet JC. Molecular actions of vitamin D contributing to cancer prevention. Mol Aspects Med. 2008;29:388–96. - PMC - PubMed
    1. Yin L, Raum E, Haug U, Arndt V, Brenner H. Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk. Cancer Epidemiol. 2009;33:435–45. - PubMed
    1. Albanes D, Mondul AM, Yu K, Parisi D, Horst RL, Virtamo J, et al. Serum 25-Hydroxy Vitamin D and Prostate Cancer Risk in a Large Nested Case-Control Study. Cancer Epidemiol Biomarkers Prev. 2011;20:1850–60. - PMC - PubMed

Publication types

MeSH terms