Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Nov 15;125(Pt 22):5257-8.
doi: 10.1242/jcs.122929.

Keratin intermediate filament proteins - novel regulators of inflammation and immunity in skin

Ryan P Hobbs  1 , Juliane C Lessard, Pierre A Coulombe
Affiliations
Comment

Keratin intermediate filament proteins - novel regulators of inflammation and immunity in skin

Ryan P Hobbs et al. J Cell Sci. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Krt1 and Krt17 regulate epidermal immunity in a distinct and context-dependent manner. Normal epidermis expresses Krt1 in the differentiating suprabasal layers, where it contributes to skin barrier homeostasis, in part by preventing the activation of the inflammasome and the processing of IL-18 (Roth et al., 2012). Upon an acute or chronic challenge to the epidermal barrier (e.g. injury, environmental irritants or cancer), several genes, including Krt17, are robustly induced in basal and suprabasal keratinocytes at the expense of Krt1 (and other differentiation-specific genes). Krt17 actively modulates intracellular signaling pathways to stimulate protein synthesis (Kim et al., 2006) and to also polarize the inflammatory response towards Th1 and/or Th17 (DePianto et al., 2010), thereby promoting keratinocyte growth and proliferation. Inflammation and normal barrier function thus can antagonize one another. bl, basal layer; sb, suprabasal layers; sc, stratum corneum (barrier proper).
See this image and copyright information in PMC

Comment on

References

    1. Coulombe P. A., Lee C. H. (2012). Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermath. J. Invest. Dermatol. 132, 763–775 10.1038/jid.2011.450 - DOI - PMC - PubMed
    1. DePianto D., Kerns M. L., Dlugosz A. A., Coulombe P. A. (2010). Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin. Nat. Genet. 42, 910–914 10.1038/ng.665 - DOI - PMC - PubMed
    1. Freedberg I. M., Tomic–Canic M., Komine M., Blumenberg M. (2001). Keratins and the keratinocyte activation cycle. J. Invest. Dermatol. 116, 633–640 10.1046/j.1523-1747.2001.01327.x - DOI - PubMed
    1. Habtezion A., Toivola D. M., Butcher E. C., Omary M. B. (2005). Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment. J. Cell Sci. 118, 1971–1980 10.1242/jcs.02316 - DOI - PubMed
    1. Kim S., Wong P., Coulombe P. A. (2006). A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature 441, 362–365 10.1038/nature04659 - DOI - PubMed

Publication types