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. 2013 Jan;5(1):51-7.
doi: 10.4103/1947-2714.106208.

Evaluation of Total Antioxidant Capacity of Saliva in Type 2 Diabetic Patients with and without Periodontal Disease: A Case-Control Study

Gowri Pendyala  1 , Biju Thomas, Saurabh R Joshi
Affiliations

Evaluation of Total Antioxidant Capacity of Saliva in Type 2 Diabetic Patients with and without Periodontal Disease: A Case-Control Study

Gowri Pendyala et al. N Am J Med Sci. 2013 Jan.

Abstract

Background: Diabetes mellitus (DM) has been linked with oxidative stress and decreased antioxidant defense. A connection has been established between diabetes and periodontal disease.

Aim: The aim of present study was to compare salivary total antioxidant capacity of type 2 DM patients and healthy subjects with and without periodontal disease.

Materials and methods: A total of 120 subjects consisting of 30 type 2 DM patients with periodontal disease; 30 type 2 DM patients without periodontal disease; 30 healthy subjects with periodontal disease; 30 healthy subjects without periodontal disease were included in the study. After clinical measurement and samplings, total antioxidant capacity in saliva of type 2 diabetic and healthy subjects were determined, and the data were tested by non-parametric tests. Total antioxidant capacity of the clinical samples was determined spectrophotometrically.

Results: The mean salivary total antioxidant capacity was lowest in diabetic patients with periodontitis.

Conclusion: Total antioxidant capacity is inversely proportional to the severity of inflammation and can be used as an useful marker of periodontitis in healthy and diabetic patients.

Keywords: Antioxidants; Diabetes mellitus; Free radicals; Periodontitis; Total antioxidant capacity.

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Conflict of interest statement

Conflict of Interest: None declared.

References

    1. van Dyke TE. Cellular and molecular susceptibility determinants for periodontitis. Periodontol 2000. 2007;45:10–3. - PubMed
    1. Marsh PD, Devine DA. How is the development of dental biofilms influenced by the host? J Clin Periodontol. 2011;38:28–35. - PubMed
    1. Fredriksson MI, Gustafsson AK, Bergström KG, Asman BE. Constitutionally hyperreactive neutrophils in periodontitis. J Periodontol. 2003;74:219–24. - PubMed
    1. Matthews JB, Wright HJ, Roberts A, Cooper PR, Chapple IL. Hyperactivity and reactivity of peripheral blood neutrophils in chronic periodontitis. Clin Exp Immunol. 2007;147:255–64. - PMC - PubMed
    1. Panjamurthy K, Manoharan S, Ramachandran CR. Lipid peroxidation and antioxidant status in patients with periodontitis. Cell Mol Biol Lett. 2005;10:255–64. - PubMed