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Review
. 2013 Feb;6(1):3-21.
doi: 10.1016/j.ajp.2012.07.012. Epub 2012 Sep 6.

Psychobiology of PTSD in the acute aftermath of trauma: Integrating research on coping, HPA function and sympathetic nervous system activity

Matthew C Morris  1 , Uma Rao
Affiliations
Review

Psychobiology of PTSD in the acute aftermath of trauma: Integrating research on coping, HPA function and sympathetic nervous system activity

Matthew C Morris et al. Asian J Psychiatr. 2013 Feb.

Abstract

Research on the psychobiological sequelae of trauma has typically focused on long-term alterations in individuals with chronic posttraumatic stress disorder (PTSD). Far less is known about the nature and course of psychobiological risk factors for PTSD during the acute aftermath of trauma. In this review, we summarize data from prospective studies focusing on the relationships among sympathetic nervous system activity, hypothalamic-pituitary-adrenal function, coping strategies and PTSD symptoms during the early recovery (or non-recovery) phase. Findings from pertinent studies are integrated to inform psychobiological profiles of PTSD-risk in children and adults in the context of existing models of PTSD-onset and maintenance. Data regarding bidirectional relations between coping strategies and stress hormones is reviewed. Limitations of existing literature and recommendations for future research are discussed.

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Conflict of interest statement

Conflict of Interest

The authors have no conflicts of interest.

Figures

Fig. 1
Fig. 1
Traumatic Stress Vulnerability Model
See this image and copyright information in PMC

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