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Comment
. 2013 Mar;182(3):623-7.
doi: 10.1016/j.ajpath.2012.12.016. Epub 2013 Feb 1.

Creationism and evolutionism in prions

Pierluigi Gambetti  1
Affiliations
Comment

Creationism and evolutionism in prions

Pierluigi Gambetti. Am J Pathol. 2013 Mar.

Abstract

This Commentary highlights the article by Ghaemmaghami et al, who investigated the nature of synthetic prion transformation and demonstrated that these can assume multiple intermediate conformations before converting into one conformation optimized for in vivo propagation.

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Figures

Figure 1
Figure 1
In-pathway intermediate states and final forms of the four synthetic prion strains, along with changes in incubation time, banding pattern, and conformational stabilities after serial passages in transgenic mice. MoSP7 generated all three strain types (indicated as a, b, and c), which traversed different intermediate states before reaching the optimal condition. Strain MoSP7c split into two distinct strains (1 and 2) at the second passage. Strain characteristics in the adapted state are highlighted in red.
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Comment on

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