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. 2013 Feb;34(2):187-8.
doi: 10.1038/aps.2012.192.

Ubiquitin-proteasome system, a new anti-tumor target

Wei Du  1 , Qi-bing Mei
Affiliations

Ubiquitin-proteasome system, a new anti-tumor target

Wei Du et al. Acta Pharmacol Sin. 2013 Feb.
No abstract available

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Figures

Figure 1
Figure 1
MLN4924 blocks NAE pathway leading to inactivation of CRLs.
See this image and copyright information in PMC

References

    1. Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, et al. Global identification of modular cullin-RING ligase substrates. Cell. 2011;147:459–74. - PMC - PubMed
    1. Soucy TA, Smith PG, Milhollen MA, Berger AJ, Gavin JM, Adhikari S, et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature. 2009;458:732–6. - PubMed
    1. Milhollen MA, Traore T, Adams-Duffy J, Thomas MP, Berger AJ, Dang L, et al. MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-kappaB-dependent lymphoma. Blood. 2012;116:1515–23. - PubMed
    1. Milhollen MA, Thomas MP, Narayanan U, Traore T, Riceberg J, Amidon BS, et al. Treatmen-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924. Cancer Cell. 2012;21:388–401. - PubMed
    1. Blank J, Liu XJ, Cosmopoulos K, Bouck DC, Garcia K, Bernard H, et al. Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924. Cancer Res. 2013;73:225–34. - PubMed

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