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Review
. 2013 Apr;13(2):196-202.
doi: 10.1007/s11882-013-0338-z.

The role of interleukin-33 in rhinitis

Barbara Rogala  1 , Joanna Glück
Affiliations
Review

The role of interleukin-33 in rhinitis

Barbara Rogala et al. Curr Allergy Asthma Rep. 2013 Apr.

Abstract

IL-33, a member of the IL-1 cytokine family and a ligand to receptor ST2, has great potential to induce a T helper 2-type inflammatory response. IL-33 is proven to be released by epithelial cells during their injury by different environmental stimuli such as airborne allergens, viruses, and air pollutants. IL-33 acting as an endogenous danger signal is termed an alarmin. As such, this cytokine is considered to play a crucial role in an allergic inflammatory disease such as rhinitis. Recent investigations regarding the IL-33/ST2 axis involvement in Th2 inflammatory response and pathogenesis of rhinitis have been reviewed. The role of IL-33 as a novel promising therapeutic target has also been discussed.

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