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Review
. 2013 Feb 1;143(2):305-314.
doi: 10.1378/chest.12-1699.

Epidemic of lung cancer in patients with HIV infection

Tiffany A Winstone  1 , S F Paul Man  2 , Mark Hull  3 , Julio S Montaner  3 , Don D Sin  4
Affiliations
Review

Epidemic of lung cancer in patients with HIV infection

Tiffany A Winstone et al. Chest. .

Abstract

The survival of patients with HIV infection has improved dramatically over the past 20 years, largely owing to a significant reduction in opportunistic infections and AIDs-defining malignancies, such as lymphoma and Kaposi sarcoma. However, with improved survival, patients with HIV are experiencing morbidity and mortality from other (non-AIDs-defining) complications, such as solid organ malignancies. Of these, the leading cause of mortality in the HIV-infected population is lung cancer, accounting for nearly 30% of all cancer deaths and 10% of all non-HIV-related deaths. Importantly, the average age of onset of lung cancer in the HIV-infected population is 25 to 30 years earlier than that in the general population and at lower exposure to cigarette smoke. This article provides an overview of the epidemiology of lung cancer in the HIV-infected population and discusses some of the important risk factors and pathways that may enhance the risk of lung cancer in this population.

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Figures

Figure 1.
Figure 1.
Incidence of lung cancer in patients with HIV infection. Incidence rates in the general population derived from the Surveillance, Epidemiology, and End Results program of the National Cancer Institute. Data from Patel et al.
Figure 2.
Figure 2.
The relationship between peripheral blood CD4 counts and the risk of lung cancer in patients with HIV infection. Data from Guiguet et al.
Figure 3.
Figure 3.
The relationship between age and the risk of lung cancer in patients with HIV infection. Data from Guiguet et al.
See this image and copyright information in PMC

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