doi: 10.1016/0014-5793(90)80750-d.
Proliferation of peroxisomes without simultaneous induction of the peroxisomal fatty acid beta-oxidation
Affiliations
- PMID: 2338145
- DOI: 10.1016/0014-5793(90)80750-d
Item in Clipboard
Proliferation of peroxisomes without simultaneous induction of the peroxisomal fatty acid beta-oxidation
FEBS Lett.
.
Free article
Abstract
Marked proliferation of rat hepatic peroxisomes is observed after treatment with a new potent hypolipidemic drug BM 15766, as well as after bezafibrate. Whereas the relative specific activity of the peroxisomal fatty acid beta-oxidation system is not affected by BM 15766 it is significantly increased after bezafibrate. This is also confirmed by immunoblot analysis of individual beta-oxidation enzymes in highly purified peroxisome fractions. These observations suggest that peroxisome proliferation and the induction of the fatty acid beta-oxidation are regulated separately.
Similar articles
-
The short- and long-term effects of bezafibrate in the rat.Ann N Y Acad Sci. 1982;386:111-35. doi: 10.1111/j.1749-6632.1982.tb21410.x. Ann N Y Acad Sci. 1982. PMID: 6953842
-
Involvement of calmodulin- and protein kinase C-related mechanism in an induction process of peroxisomal fatty acid oxidation-related enzymes by hypolipidemic peroxisome proliferators.Biochim Biophys Acta. 1992 Apr 30;1135(1):84-90. doi: 10.1016/0167-4889(92)90170-g. Biochim Biophys Acta. 1992. PMID: 1591274
-
Induction of fatty acid binding protein by peroxisome proliferators in primary hepatocyte cultures and its relationship to the induction of peroxisomal beta-oxidation.Biochim Biophys Acta. 1990 Apr 23;1034(1):53-61. doi: 10.1016/0304-4165(90)90152-m. Biochim Biophys Acta. 1990. PMID: 2328261
-
Application of in situ hybridization, cytochemical and immunocytochemical techniques for the investigation of peroxisomes. A review including novel data. Robert Feulgen Prize Lecture 1997.Histochem Cell Biol. 1997 Sep;108(3):185-210. doi: 10.1007/s004180050160. Histochem Cell Biol. 1997. PMID: 9342614 Review.
-
Detection of mRNAs encoding peroxisomal proteins by non-radioactive in situ hybridization with digoxigenin-labelled cRNAs.Histochem Cell Biol. 1997 Oct-Nov;108(4-5):371-9. doi: 10.1007/s004180050178. Histochem Cell Biol. 1997. PMID: 9387930 Review.
Cited by
-
Induction of the major integral membrane protein of mouse liver peroxisomes by peroxisome proliferators.Biochem J. 1992 Apr 15;283 ( Pt 2)(Pt 2):605-10. doi: 10.1042/bj2830605. Biochem J. 1992. PMID: 1575703 Free PMC article.
-
Contributions of the immunogold technique to investigation of the biology of peroxisomes.Histochem Cell Biol. 1996 Jul;106(1):105-14. doi: 10.1007/BF02473205. Histochem Cell Biol. 1996. PMID: 8858370 Review.
-
The peroxisome: an update on mysteries.Histochem Cell Biol. 2012 May;137(5):547-74. doi: 10.1007/s00418-012-0941-4. Epub 2012 Mar 14. Histochem Cell Biol. 2012. PMID: 22415027 Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
