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. 2013:28 Suppl 1:3-7.
doi: 10.1590/s0102-86502013001300002.

The role of gut-liver axis in the restriction of intrauterine growth in a model of experimental gastroschisis

Márcia Pereira Bueno  1 , Frances Lilian Lanhellas Gonçalves, Dioze Guadagnini, Ricardo Barini, Mario José Abdalla Saad, Rodrigo Melo Gallindo, Augusto Frederico Schmidt, Lourenço Sbragia
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The role of gut-liver axis in the restriction of intrauterine growth in a model of experimental gastroschisis

Márcia Pereira Bueno et al. Acta Cir Bras. 2013.

Abstract

Purpose: To evaluate the intrauterine growth restriction (IUGR) by the expression of IR-β, IRS-1, IRS-2, IGF-IRβ and Ikappaβ in experimental model of gastroschisis.

Methods: Pregnant rats at 18.5 days of gestation were submitted to surgery to create experimental fetal gastroschisis (term = 22 days) were divided in three groups: gastroschisis (G), control (C) and sham (S). Fetuses were evaluated for body weight (BW), intestinal (IW), liver (LW) and their relations IW/BW and LW/BW. IR-β and IGF-IRβ receptors, IRS-1 and IRS-2 substrates and Ikappaβ protein were analyzed by western blotting.

Results: BW was lower in G, the IW and IW / BW were greater than C and S (p<0.05) groups. The liver showed no differences between groups. In fetuses with gastroschisis, compared with control fetuses, the expression of IGF-IRβ (p<0.001) and Ikappaβ (p<0.001) increased in the liver and intestine, as well as IR-β (p<0.001) which decreased in both. In contrast to the intestine, IRS-1 (p<0.001) increased in the liver and IRS-2 decreased (p<0.01).

Conclusion: The axis of the intestine liver has an important role in inflammation, with consequent changes in the metabolic pathway of glucose can contribute to the IUGR in fetuses with gastroschisis.

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