Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Feb;5(2):177-9.
doi: 10.1002/emmm.201202345.

Heart to heart: grafting cardiosphere-derived cells augments cardiac self-repair by both myocytes and stem cells

Jose A Palacios  1 , Michael D Schneider
Affiliations
Comment

Heart to heart: grafting cardiosphere-derived cells augments cardiac self-repair by both myocytes and stem cells

Jose A Palacios et al. EMBO Mol Med. 2013 Feb.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. Cardiosphere-derived cells stimulate the formation of new cardiomyocytes following infarction both from preformed cardiomyocytes and from undifferentiated progenitor or stem cells
Donor cells did not stably engraft, yet conferred an improvement in cardiac structure and pump function. Fate-mapping with the Cre/lox system ascribed new cardiomyocyte creation both to proliferation of pre-existing myocytes and to the differentiation of formerly undifferentiated cells.
See this image and copyright information in PMC

Comment on

References

    1. Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabe-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, et al. Evidence for cardiomyocyte renewal in humans. Science. 2009;324:98–102. - PMC - PubMed
    1. Bolli R, Chugh AR, D'Amario D, Loughran JH, Stoddard MF, Ikram S, Beache GM, Wagner SG, Leri A, Hosoda T, et al. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet. 2011;378:1847–1857. - PMC - PubMed
    1. Eulalio A, Mano M, Ferro MD, Zentilin L, Sinagra G, Zacchigna S, Giacca M. Functional screening identifies miRNAs inducing cardiac regeneration. Nature. 2012;492:376–381. - PubMed
    1. Hesse M, Raulf A, Pilz GA, Haberlandt C, Klein AM, Jabs R, Zaehres H, Fugemann CJ, Zimmermann K, Trebicka J, et al. Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycle. Nat Commun. 2012;3:1076. - PMC - PubMed
    1. Hsieh PC, Segers VF, Davis ME, MacGillivray C, Gannon J, Molkentin JD, Robbins J, Lee RT. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med. 2007;13:970–974. - PMC - PubMed