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. 2013 Jan 28;19(4):440-4.
doi: 10.3748/wjg.v19.i4.440.

MicroRNA-feedback loop as a key modulator of liver tumorigenesis and inflammation

Angélique Gougelet  1 , Sabine Colnot
Affiliations

MicroRNA-feedback loop as a key modulator of liver tumorigenesis and inflammation

Angélique Gougelet et al. World J Gastroenterol. .

Abstract

A recent work of Iliopoulos et al published in Cell highlighted a circuit orchestrated by microRNAs (miRNAs) that results in liver tumorigenesis and inflammation. This feedback loop, governed by miR-24 and miR-629, promotes a hepatocyte nuclear factor-4α transient inhibition resulting in miR-124 induction and signal transducer and activator of transcription 3 activation. These promising data support the use of miRNA mimics or inhibitors as potent therapeutic approaches in liver cancer.

Keywords: Hepatocellular oncogenesis; Hepatocyte nuclear factor-4α; Interleukin-6; MicroRNA; Signal transducer and activator of transcription 3.

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Figures

Figure 1
Figure 1
From transient hepatocyte nuclear factor-4α inhibition to stable hepatocyte transformation. The transient inhibition of hepatocyte nuclear factor-4α (HNF-4α) following miR-24 and miR-629 induction promotes stable repression of the pro-tumorigenic HNF-4α feedback circuit. This results in miR-124 inhibition, followed by an increase in interleukin (IL)-6 secretion and IL-6R expression. These two events lead to hyperphosphorylation of signal transducer and activator of transcription 3 (STAT3), which auto-amplifies the process through the re-induction of miR-24 and miR-629.
See this image and copyright information in PMC

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