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. 2012 Sep;12(3):249-58.
doi: 10.4314/ahs.v12i3.2.

The long-term effectiveness of generic adult fixed-dose combination antiretroviral therapy for HIV-infected Ugandan children

L N Barlow-Mosha  1 , D S Bagenda, P K Mudiope, M C Mubiru, L M Butler, M G Fowler, P M Musoke
Affiliations

The long-term effectiveness of generic adult fixed-dose combination antiretroviral therapy for HIV-infected Ugandan children

L N Barlow-Mosha et al. Afr Health Sci. 2012 Sep.

Abstract

Background: Access to pediatric antiretroviral formulations is increasing in resource-limited countries, however adult FDCs are still commonly used by antiretroviral therapy (ART) programs.

Objective: To describe long-term effectiveness of using adult FDC of d4T+3TC+NVP (Triomune) in children for HIV treatment.

Methods: Clinical, immunologic, and virologic outcomes of HIV-infected ART-naïve children aged six months to 12 years, were evaluated up to 96 weeks post-ART initiation.

Results: From March 2004 to June 2006, 104 children were followed with a median age of 5.4 years, median CD4 cell percent and HIV-1 RNA were 11.0% (IQR 6.7-13.9) and 348,846copies/mL (IQR 160,941-681,313) respectively at baseline. Using Kaplan-Meir estimates, 75% of children had undetectable viral loads (<400copies/mL) at 96 weeks of ART. Children with a baseline CD4 cell percent >15% were 3 times more likely to achieve viral load <400copies/mL than those with baseline CD4 cell percent <5% after adjusting for baseline age {aHR = 3.03 (1.10-8.32), p=0.03}; no difference was found among those with CD4 cell percent >5-14.9% and <5%.

Conclusion: Treatment with generic adult FDC for HIV-infected Ugandan children led to sustained clinical, immunologic and virologic response during 96 weeks of ART. Early initiation of ART is key to achieving virological success.

Keywords: Children; HIV; Sub-Saharan Africa; antiretroviral treatment; fixed dose combination.

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Figures

Figure 1
Figure 1
Program profile
Figure 2a
Figure 2a
Proportion of children on generic adult FDC HAART (Triomune) achieveing viral load <400 copies/ML
Figure 2b
Figure 2b
Proportion of children on generic adult FDC HAART (Triomune) achieveing viral load <400 copies/ML stratified by baseline CD4 cell percent
Figure 3a
Figure 3a
Proportion of HIV-ienfected children on generic adult FDC HAART (Triomune achieving viral load <400 copies/ML
Figure 3b
Figure 3b
Mean CD4 cell percent over time among HIV-infected children treated with generic FDC ART (Triomune) with 95% CIs
See this image and copyright information in PMC

References

    1. UNAIDS/WHO, author. Report on Global AIDS Epidemic. 2010. Available at: http://www.unaids.org/globalreport/global_report.htm.
    1. Sutcliffe CG, van Dijk JH, Bolton C, Persaud D, Moss WJ. Effectiveness of antiretroviral therapy among HIV-infected children in sub-Saharan Africa. Lancet Infect Dis. 2008;8(8):477–489. - PubMed
    1. Marum L BD, Guay L, et al. Three year mortality in a cohort of HIV -1 infected and uninfected Ugandan Children, Abstract WeB312; XI International Conference on AIDS STD: July 1996; Vancouver; 1996.
    1. De Baets AJ, Bulterys M, Abrams EJ, Kankassa C, Pazvakavambwa IE. Care and treatment of HIV-infected children in Africa: issues and challenges at the district hospital level. Pediatr Infect Dis J. 2007;26(2):163–173. - PubMed
    1. Ministry of Health personal communication. 2010

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