doi: 10.1021/ol400045d.
Epub 2013 Feb 5.
XtalFluor-E, an efficient coupling reagent for amidation of carboxylic acids
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- PMID: 23383604
- DOI: 10.1021/ol400045d
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XtalFluor-E, an efficient coupling reagent for amidation of carboxylic acids
Org Lett.
.
Abstract
Amides were produced from carboxylic acids and amines by using XtalFluor-E as an activator. Even poorly reactive carboxylic acids can be transformed to amides. In addition, optically active amines and/or carboxylic acids were not epimerized/racemized during the process.
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