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. 2013 Feb 15;15(4):902-5.
doi: 10.1021/ol400045d. Epub 2013 Feb 5.

XtalFluor-E, an efficient coupling reagent for amidation of carboxylic acids

Aurélie Orliac  1 , Domingo Gomez Pardo, Agnès Bombrun, Janine Cossy
Affiliations

XtalFluor-E, an efficient coupling reagent for amidation of carboxylic acids

Aurélie Orliac et al. Org Lett. .

Abstract

Amides were produced from carboxylic acids and amines by using XtalFluor-E as an activator. Even poorly reactive carboxylic acids can be transformed to amides. In addition, optically active amines and/or carboxylic acids were not epimerized/racemized during the process.

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