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. 1990 Mar;14(2):97-100.
doi: 10.1007/BF00154208.

Antilens antibodies in cataract and inflammatory eye disease: an evaluation of a new technique

M Patel  1 , B Shine, P I Murray
Affiliations

Antilens antibodies in cataract and inflammatory eye disease: an evaluation of a new technique

M Patel et al. Int Ophthalmol. 1990 Mar.

Abstract

A new technique measuring serum antoantibodies to lens proteins, employing antigen linked to magnetisable cellulose particles and fluorescent end-point detection, was used to examine patients with senile cataract and inflammatory eye disease. 40% of patients with senile cataract had antibodies to lens proteins, as did 28% of patients with heterochromic cyclitis and 20% of patients with uveitis, while there were no positive sera from patients with scleritis. The single patient with lens-induced uveitis had a high titre, but so did some patients with senile cataract. With the incorporation of a standard curve this technique offers a reliable quantitative assay for lens autoantibodies. It may provide a valuable tool for the investigation of pathogenetic mechanisms in cataract and inflammatory eye disease.

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