Copper-catalyzed three-component carboboration of alkynes and alkenes

Abstract

Carboboration of alkynes was found to take place efficiently by a three-component coupling reaction with diboron and carbon electrophiles under copper catalysis to afford diverse multisubstituted borylalkenes in a stereoselective manner. The carboboration was also applicable to alkenes, leading to the formation of multisubstituted borylalkanes via regioselective carbon-boron and carbon-carbon bond-forming processes.