Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2013 May;129(2):318-23.
doi: 10.1016/j.ygyno.2013.01.026. Epub 2013 Feb 4.

The Peru Cervical Cancer Prevention Study (PERCAPS): the technology to make screening accessible

Kimberly L Levinson  1 , Carolina Abuelo, Jorge Salmeron, Eunice Chyung, Jing Zou, Suzanne E Belinson, Guixiang Wang, Carlos Santos Ortiz, Carlos Santiago Vallejos, Jerome L Belinson
Affiliations
Clinical Trial

The Peru Cervical Cancer Prevention Study (PERCAPS): the technology to make screening accessible

Kimberly L Levinson et al. Gynecol Oncol. 2013 May.

Abstract

Objective: This study utilized a combination of HPV self-sampling, iFTA elute specimen cards, and long distance transport for centralized processing of specimens to determine the feasibility of large-scale screening in remote and transient populations.

Methods: This study was performed in two locations in Peru (Manchay and Iquitos). The "Just For Me" cervico-vaginal brush and iFTA elute cards were used for the collection and transport of specimens. Samples were shipped via FedEx to China and tested for 14 types of high-risk HPV using PCR based MALDI-TOF. HPV positive women were treated with cryotherapy after VIA triage, and followed-up with colposcopy, biopsy, ECC, and repeat HPV testing at 6 months.

Results: Six hundred and forty three women registered, and 632 returned a sample over a 10 day period. Within 2 weeks, specimens were shipped, samples tested, and results received by study staff. Sixty-eight women (10.8%) tested positive, and these results were delivered over 4 days. Fifty-nine HPV positive women (87%) returned for evaluation and treatment, and 2 had large lesions not suitable for cryotherapy. At 6 months, 42 women (74%) returned for follow-up, and 3 had CIN 2 (all positive samples from the endocervical canal). Ninety eight percent of participants reported that they would participate in this type of program again.

Conclusions: Utilizing HPV self-sampling, solid media specimen cards for long distance transport, and centralized high throughput processing, we achieved rapid delivery of results, high satisfaction levels, and low loss to follow-up for cervical cancer screening in remote and transient populations.

Trial registration: ClinicalTrials.gov NCT01338051.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Statement:

Preventive Oncology International has received support in kind (reagents and testing) and/or funds for direct support and research from Hologic Inc., Qiagen, Gen-Probe, Merck Inc., BGI Shenzhen, and GE Healthcare.

Figures

Figure 1
Figure 1
Exclusion and Inclusion criteria for the study
Figure 2
Figure 2
HPV Self-Sampling Instruction Sheet
Figure 3
Figure 3
Overall participation flowsheet for both Manchay and Iquitos
See this image and copyright information in PMC

References

    1. Globocan 2008 Cancer Fact Sheet. Globocan 2008 (IARC) [cited Nov 19, 2011]. Available at: http://globocan.iarc.fr/factsheets/cancers/cervix.asp.
    1. Globocan 2008 Fast Stats: Peru. Globocan 2008 (IARC) [cited Nov 19, 2011]. Available at: http://globocan.iarc.fr/factsheets/populations/factsheet.asp?uno=604#WOMEN.
    1. Walboomers JM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189(1):12–9. - PubMed
    1. Denny L, Kuhn L, Hy C, Tsai W, Wright TC. Human Papillomavirus-Based Cervical Cancer Prevention: Long-term Results of a Randomized Screening Trial. JNCI. 2010;102:1557–1567. - PubMed
    1. Zhao F, Lewkowitz AK, Chen F, Lin M, Hu S, Zhang X, et al. Pooled Analysis of a Self-Sampling HPV DNA Test as a Cervical Cancer Primary Screening Method. JNCI. 2012;104(3):178–88. - PMC - PubMed

Publication types

MeSH terms

Associated data